The vet may have recommended clomipramine to help Zeke cope with his separation anxiety or conflict with your other pets. Clomipramine is approved for use in humans under the brand name Anafranil and as Clomicalm for dogs. Clomipramine has potential side effects, but it's generally safe with veterinary guidance.
Dogs aren't immune to stress, although they usually bounce back from a brief episode to carry on in their normal, happy fashions. However, some dogs experience chronic anxiety issues. Your pup may have separation anxiety, stressing every day when you leave the house. Perhaps he and another pet aren't happy housemates. If behavior modification hasn't worked, the vet may recommend medication to soothe his frazzled nerves. Clomipramine is a tricyclic antidepressant, believed to effect serotonin to promote soothing, comfortable feelings. Vets prescribe it for issues with anxiety, obsessive compulsive behavior and aggressive and dominance behavior. If Zeke's been prescribed clomipramine, it might take several weeks for you to see the impact on his behavior. Potential side effects include diarrhea, vomiting, increased drinking from dry mouth, increased eye pressure, difficulty urinating, disturbance in heart rhythm and decreased intestinal motility. It can interact with a variety of other medication, so it's important your vet has a complete list of medication Zeke takes, including tick and mite preventatives. Sharing his medical history is essential as clomipramine can increase the risk of seizures and aggravate glaucoma.