Flea and tick control has come a long way since the days of baths and dips. The invention of monthly preventives has not only been convenient for owners, but has also been effective in controlling flea and tick infestations. However, since topical preventives typically contain pesticides, not all of them are safe.
ProMeris was a waterproof topical preventive introduced in 2007. The pharmaceutical company Pfizer discontinued its distribution in 2011. It's purpose was to control fleas, ticks, chewing lice and Demodectic mange on dogs 8 weeks or older. It was effective for up to 6 weeks. The two main active ingredients were metaflumizone and amitraz. The side effects of metaflumizone included loss of coordination, decreased body weight and liver toxicity. Side effects of amitraz involved sedation and lethargy up to 72 hours, a slowed heart rate and vomiting and diarrhea. A study by Veterinary Dermatology also linked ProMeris to an autoimmune skin disease known as pemphigus foliaceus. This disease typically causes lesions around the face and tips of ears. These lesions were also found at the site where ProMeris had been applied. At the time of its recall, Pfizer did not have plans to replace it with a similar product.
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